Success stories
These pages highlight a small selection of completed research projects funded by the Dr Hadwen Trust, showcasing particular successes in replacing animal experiments and advancing medical progress.
TMS and brain function
Dr Hadwen Trust Research Fellowship 1998 — 2001
Using Transcranial Magnetic Stimulation (TMS) to model brain damage in human subjects
V Walsh, M Rushworth and A Ellison, then at the Department of Experimental Psychology, University of Oxford
This Dr Hadwen Trust research grant to develop transcranial magnetic stimulation (TMS) has had wide-reaching applications, as the technique is now used internationally in neuroscience research, often in place of non-human primates.
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Metabolism matters
Dr Hadwen Trust Research Fellowship 2002 — 2004
Comparison between allometric scaling and in vitro-in vivo extrapolation to predict human xenobiotic clearance
N Proctor, A Rostami-Hodjegan and G Tucker, Molecular Pharmacology and Pharmacogenetics, Sheffield University
The world’s most powerful drug agency, the US Food and Drug Administration (FDA), has pointed out that 92% of novel drugs entering clinical trials never reach the market, failing mainly because of safety or efficacy problems.
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Meningitis in cell culture
Dr Hadwen Trust Research Fellowship 1999 — 2003
Meningeal-meningococcal interactions in a novel primary human cell culture: the role of differential gene expression
D Ala’Aldeen, K Wooldridge, D Wells and M Taraktsoglou, Molecular Bacteriology and Immunology Group, University of Nottingham
Meningitis, inflammation of the meninges, is caused by infectious micro-organisms. Meningitis following infection by the bacterium Neisseria meningitidis can be severe and life threatening, especially in the young.
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