Articles & posters
Dr Hadwen Trust articles and posters
The Dr Hadwen Trust for Humane Research has published a number of papers, reviews and posters focused on the replacement of animal experiments in medical research and toxicology. The publications listed were written or co-written by staff at the Dr Hadwen Trust. Our most recent articles and posters are listed below. Archived publications are accessed via the right-hand pane.
Langley G (2008). Cancer and wound healing – in-vitro insights. Laboratory News January 2008:14-15.
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Langley G (2008). Reply to Festing (correspondence). BioEssays 30:96-97.
Langley G, Evans T, Holgate ST et al (2007). Replacing animal experiments: Choices, chances and challenges. BioEssays 29:918-926.
Abstract: Replacing animal procedures with methods such as cells and tissues in vitro, volunteer studies, physicochemical techniques and computer modelling, is driven by legislative, scientific and moral imperatives. Non-animal approaches are now considered as advanced methods which can overcome many of the limitations of animal experiments. In testing medicines and chemicals, in vitro assays have spared hundreds of thousands of animals. In contrast, academic animal use continues to rise and the concept of replacement seems less well accepted in university research. Even so, some animal procedures have been replaced in neurological, reproductive and dentistry research and progress is being made in fields such as respiratory illnesses, pain and sepsis. Systematic reviews of the transferability of animal data to the clinical setting may encourage a fresh look for novel non-animal methods, and as mainstream funding becomes available, more advances in replacement are expected.
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Gordon N & Langley G (2007). Comment on the Talking Points in EMBO Reports. EMBO Reports 8:794.
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Langley G & Newman C (2007). Poster presented at the 2007 stakeholder meeting at the National Centre for the Replacement, Refinement and Reduction of Animals in Research, January 2007.
Abstract: Three success stories in replacing animal experiments and advancing medicine are described: computer simulations in reproductive physiology; novel imaging and related techniques applied to volunteers in CNS research; and the development of mass spectral patterns to identify bacterial strains in disease control.
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Coecke S, Blaauboer BJ, Elaut G et al (2005). Toxicokinetics and Metabolism. In: Alternative (Non-Animal) Methods for Cosmetics Testing: Current Status and Future Prospects. A report prepared in the context of the 7th Amendment of the Cosmetics Directive. ATLA 33(Suppl. 1):147-175.
Medline link
Diembeck W, Eskes C, Heylings JR et al (2005). Skin Absorption and Penetration. In: Alternative (Non-Animal) Methods for Cosmetics Testing: Current Status and Future Prospects. A report prepared in the context of the 7th Amendment of the Cosmetics Directive. ATLA 33(Suppl. 1):105-107.
Medline link
Langley C, Brock C, Brouwer G et al (2005). Opportunities to replace the use of animals in sepsis research. The report and recommendations of a Focus on Alternatives Workshop. ATLA 33:641-648.
Abstract: Sepsis and multiple organ failure are common causes of death in patients admitted to intensive care units. The incidence of sepsis and associated mortalities has been steadily increasing over the past 20 years. Sepsis is a complex inflammatory condition, the precise causes of which are still poorly understood. Animal models of sepsis have the potential to cause substantial suffering, and many of them have been poorly representative of the human syndrome. However, a number of non-animal approaches, including in vitro, in silico and clinical studies, show promise for addressing this situation. This report is based on discussions held at an expert workshop convened by Focus on Alternatives and held in 2004 at the Wellcome Trust, London. It provides an overview of some non-animal approaches to sepsis research, including their strengths and weaknesses, and argues that they should be prioritised for further development.
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Newman C (2005). Replacement of animal experiments is the ultimate aim. School Science Review, 87:115-120.
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Brock C, Langley G & Newman C (2004). Report of a meeting to discuss a National Centre for the Replacement of Animal Experiments. ATLA 32:11-15.
Abstract: Following the publication of their joint proposal for a National Centre for the Replacement of Animals In Experiments in 2002, the Dr Hadwen Trust and the Lord Dowding Fund organised a meeting, held on 18 November 2003 at Portcullis House, Westminster, in London, in order to discuss the concept further. A one-page summary of their proposal is attached as an appendix, and full copies are available from the Lord Dowding Fund and the Dr Hadwen Trust. The meeting aimed to discuss the need to stimulate and promote research to replace animal experiments by means of a National Centre (a coordinating body), and how this should be established and funded. Participants, numbering about 80 in total, included politicians (national and European), government officials, scientists, funding bodies and animal welfare representatives. this report is a summary of the issues raised by speakers and other participants at the meeting.
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Newman C (2003). Serum-free cell culture – the ethical, scientific and economic choice. The Biomedical Scientist 47:941-942.
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Langley G (2003). The Case Against the Use of Animals in Medical Experiments. In: R Levinson & MJ Reiss (eds), Key Issues in Bioethics: A guide for teachers. London: RoutledgeFalmer. ISBN: 9780415309141
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Jenkins ES & Langley G (2002). Adoption of animal welfare principles by UK regulators. Toxicology 176:245-251.
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Langley G, Harding G, Hawkins P et al (2000). Volunteer studies replacing animal experiments in brain research. Report and recommendations of a Volunteers in Research & Testing Workshop. ATLA 28:315-331.
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Langley G, Broadhead C, Bottrill K et al (1999). Accessing information on the reduction, refinement and replacement of animal experiments. Report and recommendations of a Focus on Alternatives workshop. ATLA 27:239-245.
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Langley G (1998). Biopharmaceuticals — from animals or plants? ATLA (editorial) 26:569-570.
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Langley G (1997). Animal Tests and Alternatives: An Animal Protection Viewpoint. In: Animal Alternatives, Welfare and Ethics: Proceedings of the Second World Congress on Alternatives and Animal Use in the Life Sciences. Developments in Animal & Veterinary Sciences 27:347-354.
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Lewis DFV & Langley GR (1996). A Validation Study of COMPACT and HazardExpert Techniques with 40 chemicals. Mut Res 369:157-174.
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